Synthesis, biological activity of newly designed sulfonamide based indole derivative as anti-microbial agent

Abstract Background In medicinal chemistry, indole and its derivative play an important role. Indole is gaining a lot of importance in chemistry due to physiological activity which includes anticancer, antitubercular, antimicrobial, antiviral, antimalarial, anti-inflammatory activities, antileishmanial agents, anti-cholinesterase, enzyme inhibitory. The spread antimicrobial resistance becomes threat both humans animals. Antimicrobial has been declared the top 10 global major health risks by WHO including reported data 2020 AMR with 3,106,002 confirmed infections across 70 countries. Result this present work some new sulfonamide-based derivatives were synthesized using 1H-indole -2 carboxylic acid as starting material. structure all was 1H NMR LCMS Spectroscopy. Conclusion All compounds screened for anti-microbial against Gram Positive Staphylococcus aureus, Bacillus megaterium, Negative Klebsiella pneumonia, Escherichia coli, Salmonellatyphiae , Shigella sp., Enterobacter aerogenes. Among gram-positive megaterium. compound shows among gram-negative bacteria pneumonia good activity.